A Novel Aldehyde Dehydrogenase-3 Activator (Alda-89) Protects Submandibular Gland Function from Irradiation without Accelerating Tumor Growth Running Title: ALDH3 activation reduces RT-induced xerostomia
نویسندگان
چکیده
Author Contributions: Nan Xiao: Conception and design, aquisition of data, manuscript writing Hongbin Cao: Aquisition of data, analysis and interpretation of data Che-Hong Chen: Conception and design Christina S. Kong: Aquisition of data, analysis and interpretation of data Rehan Ali:Aquisition of data, analysis and interpretation of data Cato Chan: Administrative and material support Davud Sirjani: Material support Edward Graves: Conception and design Albert Koong: Conception and design, manuscript writing Amato Giaccia: Conception and design, manuscript writing Daria Mochly-Rosen: Conception and design, manuscript writing Quynh-Thu Le: Conception and design, manuscript writing, final approval of manuscript
منابع مشابه
A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth.
PURPOSE To determine the effect of Alda-89 (an ALDH3 activitor) on (i) the function of irradiated (radiotherapy) submandibular gland (SMG) in mice, (ii) its toxicity profile, and (iii) its effect on the growth of head and neck cancer (HNC) in vitro and in vivo. EXPERIMENTAL DESIGN Adult mice were infused with Alda-89 or vehicle before, during, and after radiotherapy. Saliva secretion was moni...
متن کاملCancer Therapy: Preclinical A Novel Aldehyde Dehydrogenase-3 Activator (Alda-89) Protects Submandibular Gland Function from Irradiation without Accelerating Tumor Growth
Purpose: To determine the effect of Alda-89 (an ALDH3 activitor) on (i) the function of irradiated (radiotherapy) submandibular gland (SMG) inmice, (ii) its toxicity profile, and (iii) its effect on the growth of head and neck cancer (HNC) in vitro and in vivo. Experimental Design: Adult mice were infused with Alda-89 or vehicle before, during, and after radiotherapy. Saliva secretion was monit...
متن کاملHuman Cancer Biology A Novel Aldehyde Dehydrogenase-3 Activator Leads to Adult Salivary Stem Cell Enrichment In Vivo
Purpose: To assess aldehyde dehydrogenase (ALDH) expression in adult human and murine submandibular gland (SMG) stem cells and to determine the effect of ALDH3 activation in SMG stem cell enrichment. Experimental Design: Adult human and murine SMG stem cells were selected by cell surface markers (CD34 for human and c-Kit formouse) and characterized for various other stem cell surfacemarkers by ...
متن کاملA novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo.
PURPOSE To assess aldehyde dehydrogenase (ALDH) expression in adult human and murine submandibular gland (SMG) stem cells and to determine the effect of ALDH3 activation in SMG stem cell enrichment. EXPERIMENTAL DESIGN Adult human and murine SMG stem cells were selected by cell surface markers (CD34 for human and c-Kit for mouse) and characterized for various other stem cell surface markers b...
متن کاملQuantitative assessment of salivary gland function by radioisotopic scanning in a randomized trial of Pilocarpine for prevention of radiation induced Xerostomia [Persian]
Introduction: Radioisotope scanning is the best method for objective assessment of salivary gland function. Thus, it was used in a randomized trial of concomitant pilocarpine for assessment of radiation-induced xerostomia, in addition to subjective evaluation by an approved questionnaire and objective standard xerostomia grading. Methods: Patients randomized in placebo-controlled trial of...
متن کامل